Tafadhali subiri… Kivuli

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  • 2022-02-15Imesasishwa
Tafadhali subiri… Kivuli
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tocolSystematicReviewTechnicalNoteTutorialViewpoint  AdvancedSearch SectionSpecialIssueVolumeIssueNumberPe LogicalOperatorOperatorANDORSearchTextSearchTypeAllfieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFullTextReferences add_circle_outlineremove_circle_outline  CancersTheRoleofMacrophesinSarcomaTumorMicroenvironmentandTreatmentMathematicsHom-LieSuperalgebrasinCharacteristic2VirusesNeckandBaseplateModelofPheTP901-1RemoteSensingPlanetaryRadar—State-of-the-ArtReviewRecentArticles 19pes,2684KiB OpenAccessArticleAC-Winding-ResistanceCalculationofToroidalInductorswithSolid-Round-WireandLitz-WireWindingBasedonComplexPermeabilityModelingbyDae-YongUm,Seung-AhnChaeandGwan-SooParkMachines2024,12(4),228;doi.org/10.3390/machines(registering DOI)-28Mar2024AbstractThispaperhasinvestigatedamethodforcalculatingthefrequency-dependentwindingresistanceoftoroidalinductorwindingswithLitz-wireaswellassolid-roundwire.ThemodifiedDowell’smodelisemployedtoaddresstheeffectivenessforinductorwindingswiththelowandhighfillingfactors.[...]Readmore.Thispaperhasinvestigatedamethodforcalculatingthefrequency-dependentwindingresistanceoftoroidalinductorwindingswithLitz-wireaswellassolid-roundwire.ThemodifiedDowell’smodelisemployedtoaddresstheeffectivenessforinductorwindingswiththelowandhighfillingfactors.Toovercomethelimitationofthismodel,especiallyforawindingdenselywoundaroundthecore,analternativeapproachbasedonthecomplexpermeabilityanditerativecalculationsisproposed.ForthecalculatedAC-resistancefactoroffiveinductorswithdifferentnumbersofturns,layerswiththesamewirediametersarecomparedwiththatofFEA,andthethreeair-coretoroidalwindingsaremanufacturedandtestedwithinthefrequencywheretheself-resonancecanbeneglected.TheproposedmodeldemonstratestheversalityoftheAC-resistancecalculationofbothsolid-andLitz-wirewindingswithinanerrorof15%acrossawiderangeoffrequenciesupto1MHz,comparedwithFEA.Fullarticle(ThisarticlebelongstotheSectionElectricalMachinesandDrives)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,198KiB)16pes,1597KiB OpenAccessArticleEnhancingGlucoseBiosensingwithGrapheneOxideandFerrocene-ModifiedLinearPoly(ethylenimine)byJirawanMonkrathok,PattanaphongJanphuang,SomphongSuphachiaraphan,SastiyaKampaengsri,AnyaneeKamkaew,KantapatChansaenpakTafadhali subiri… Kivuli,SireeratLisnund,VincentBlayandPiyanutPinyouBiosensors2024,14(4),161;doi.org/10.3390/bios(registering DOI)-28Mar2024AbstractWedesignedandoptimizedaglucosebiosensorsystembasedonascreen-printedelectrodemodifiedwiththeNAD-GDHenzyme.Toenhancetheelectroactivesurfaceareaandimprovetheelectrontransferefficiency,weintroducedgrapheneoxide(GO)andferrocene-modifiedlinearpoly(ethylenimine)(LPEI-Fc)ontothebiosensor[...]Readmore.Wedesignedandoptimizedaglucosebiosensorsystembasedonascreen-printedelectrodemodifiedwiththeNAD-GDHenzyme.Toenhancetheelectroactivesurfaceareaandimprovetheelectrontransferefficiency,weintroducedgrapheneoxide(GO)andferrocene-modifiedlinearpoly(ethylenimine)(LPEI-Fc)ontothebiosensorsurface.Thisstrategicmodificationexploitstheelectrostaticinteractionbetweengrapheneoxide,whichpossessesanegativecharge,andLPEI-Fc,whichispositivelycharged.Thisinteractionresultsinincreasedcatalyticcurrentduringglucoseoxidationandhelpsimprovetheoverallglucosedetectionsensitivitybyamperometry.Weintegratedthedevelopedglucosesensorintoaflowinjection(FI)system.Thisintegrationfacilitatesaswiftandreproducibledetectionofglucose,anditalsomitigatestheriskofcontaminationduringtheanalyses.TheincorporationofanFIsystemimprovestheefficiencyofthebiosensor,ensuringpreciseandreliableresultsinashorttime.Theproposedsensorwasoperatedataconstantappliedpotentialof0.35V.Afteroptimizingthesystem,alinearcalibrationcurvewasobtainedfortheconcentrationrangeof1.0–40mM(R2=0.986).TheFIsystemwassuccessfullyappliedtodeterminetheglucosecontentofacommercialsportsdrink.Fullarticle(ThisarticlebelongstotheSpecialIssueBiosensingforPoint-of-CareDinostics)16pes,1727KiB OpenAccessArticleEmbeddedParticleSizeMeasurementMethodofMetalMineralPolishedSectionUsingGaussianMixtureModelBasedonExpectationMaximizationAlgorithmbyHaoPeng,ChaoxiLuo,LifangHeandHaopoTangMinerals2024,14(4),358;doi.org/10.3390/min(registering DOI)-28Mar2024AbstractThestudyofprocessmineralogyplaysaveryimportantroleinthefieldofmineralprocessingandmetallurgy,inwhichthemeasurementofmineral-embeddedparticlesizeisoneofthemainresearchareas.Themanualmeasurementmethodusingamicroscopehasmanyproblems,[...]Readmore.Thestudyofprocessmineralogyplaysaveryimportantroleinthefieldofmineralprocessingandmetallurgy,inwhichthemeasurementofmineral-embeddedparticlesizeisoneofthemainresearchareas.Themanualmeasurementmethodusingamicroscopehasmanyproblems,suchasheyworkloadandlowmeasurementaccuracy.Inordertosolvethisproblem,thispaperproposesaGaussianmixturemodelbasedonanexpectationmaximization(EM)algorithmtomeasuretheembeddedparticlesizesofmineralsofpolishedmetalsections.Experimentsarehereperformedonthepolishedsectionimesofilmeniteandpyrite,andwecomparedtheresultswithamicroscope.Theexperimentalresultsshowthattheproposedmethodhashigherprecisionandaccuracyinmeasuringtheembeddedparticlesizesofmetalminerals.Fullarticle(ThisarticlebelongstotheSectionMineralProcessingandExtractiveMetallurgy)14pes,279KiB OpenAccessArticleThomasAquinasandSomeNeo-ThomistsonthePossibilityofMiraclesandtheLawsofNaturebyIgnacioSilvaReligions2024,15(4),422;doi.org/10.3390/rel(registering DOI)-28Mar2024AbstractThispaperdiscusseshowThomasAquinasandsomeNeo-Thomistsscholars(JuanJoséUrráburu,JosephHontheim,ÉdouardHugon,andJosephGredt)analysedthemetaphysicalpossibilityofmiracles.MymaingoalistounpackthemetaphysicaltoolboxthatAquinasusestosolvethebasicquestion[...]Readmore.ThispaperdiscusseshowThomasAquinasandsomeNeo-Thomistsscholars(JuanJoséUrráburu,JosephHontheim,ÉdouardHugon,andJosephGredt)analysedthemetaphysicalpossibilityofmiracles.MymaingoalistounpackthemetaphysicaltoolboxthatAquinasusestosolvethebasicquestionaboutthepossibilityofmiraclesandtocomparehowhislatenineteenth-andearlytwentieth-centuryfollowerssolvedtheissuethemselves.Thekeyfeaturetodifferentiatethetwoapproacheswillresideintheiruseofdifferentnotionstoaccountforthepossibilityofmiracles,namelyobedientialpotencyforAquinasandthelawsofnaturefortheNeo-Thomists.Toshowwhyneo-Thomistscholarssourcetothisnotion,Ialsobrieflydiscusshowthenotionofthelawsofnatureemergedintheseventeenthcentury.Fullarticle(ThisarticlebelongstotheSpecialIssueAquinasandtheSciences:ExploringthePast,Present,andFuture)15pes,2498KiB OpenAccessArticleFirstResultsonthePresenceofMycotoxinsintheLiverofPregnantFallowDeer(Damadama)HindsandFetusesbyIstvánLakatos,BiankaBabarczi,ZsófiaMolnár,ArnoldTóth,GabriellaSkoda,GyőzőF.Horváth,AdriennHorváth,DánielTóth,FarkasSükösd,LászlóSzemethyandZsuzsannaSzőkeAnimals2024,14(7),1039;doi.org/10.3390/ani(registering DOI)-28Mar2024AbstractReproductiveabnormalitieshebeenobservedinfallowdeerpopulationsinHungary.Wesupposedmycotoxincontaminationtobeoneofthepossiblecausesbecausemulti-mycotoxincontaminationisknowntobedangerousevenatlowtoxinlevels,especiallyforyounganimals.Weinvestigatedthespatial[...]Readmore.ReproductiveabnormalitieshebeenobservedinfallowdeerpopulationsinHungary.Wesupposedmycotoxincontaminationtobeoneofthepossiblecausesbecausemulti-mycotoxincontaminationisknowntobedangerousevenatlowtoxinlevels,especiallyforyounganimals.Weinvestigatedthespatialpatternofmycotoxinoccurrencesandtherelationshipbetweenmaternalandfetalmycotoxinlevels.Atotalof72fallowdeerembryosandtheirmothersweresampledinsevenforestedregionsinHungaryinthe2020/2021huntingseason.WeanalyzedAflatoxin(AF),Zearalenone(ZEA),FumonizinB1(FB1),DON,andT2-toxinconcentrationsinmaternalandfetalliversbyELISA.AFwaspresentin70%and82%,ZEAin41%and96%,DONin90%and98%,T2-toxinin96%and85%,andFB1in84%and3%ofhindandfetuslivers,respectively.Allmycotoxinspassedintothefetus,butonlyFumonizinB1rarelypassed.Theindividualvariabilityofmycotoxinlevelswasextremelyhigh,butthespatialdifferencesweremoderate.Wecouldnotprovearelationbetweenthematernalandfetalmycotoxinconcentrations,butwefoundanaccumulationofZEAandDONinthefetuses.Theseresultsreflectthepossiblethreatsofmycotoxinstothepopulationdynamicsandreproductionofwildfallowdeer.Fullarticle(ThisarticlebelongstotheSectionWildlife)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure726pes,711KiB OpenAccessReviewAComprehensiveReviewonShigaToxinSubtypesandTheirNiche-RelatedDistributionCharacteristicsinShiga-Toxin-ProducingE.coliandOtherBacterialHostsbyXuanWang,DanielYu,LindaChui,TiantianZhou,YuFeng,YuhaoCaoandShuaiZhiMicroorganisms2024,12(4),687;doi.org/10.3390/microorganisms(registering DOI)-28Mar2024AbstractShigatoxin(Stx),themainvirulencefactorofShiga-toxin-producingE.coli(STEC),wasfirstdiscoveredinShigelladysenteriaestrains.WhileseveralotherbacterialspecieshesincebeenreportedtoproduceStx,STECposesthemostsignificantrisktohumanhealthduetoits[...]Readmore.Shigatoxin(Stx),themainvirulencefactorofShiga-toxin-producingE.coli(STEC),wasfirstdiscoveredinShigelladysenteriaestrains.WhileseveralotherbacterialspecieshesincebeenreportedtoproduceStx,STECposesthemostsignificantrisktohumanhealthduetoitswidespreadprevalenceacrossvariousanimalhoststhatheclosecontactwithhumanpopulations.Basedonitsbiochemicalandmolecularcharacteristics,Shigatoxincanbegroupedintotwotypes,Stx1andStx2,amongwhichavarietyofvariantsandsubtypeshebeenidentifiedinvariousbacteriaandhostspecies.Interestingly,thedifferentStxsubtypesappeartovaryintheirhostdistributioncharacteristicsandintheseverityofdiseasesthattheyareassociatedwith.Assuch,thisreviewprovidesacomprehensiveoverviewonthebacterialspeciesthathebeenrecordedtopossessstxgenestodate,withaspecificfocusonthevariousStxsubtypevariantsdiscoveredinSTEC,theirprevalenceincertainhostspecies,andtheirdisease-relatedcharacteristics.ThisreviewprovidesabetterunderstandingoftheStxsubtypesandhighlightstheneedforrapidandaccurateapproachestotoxinsubtypingfortheproperevaluationofthehealthrisksassociatedwithShiga-toxin-relatedbacterialfoodcontaminationandhumaninfections.Fullarticle(ThisarticlebelongstotheSpecialIssueShiga-ToxinProducingEscherichiacoliandtheAnimalHost)9658;9660;ShowFiguresFigure112pes,734KiB OpenAccessReviewEntericNervousSystemAlterationsinInflammatoryBowelDisease:PerspectivesandImplicationsbyShubhankarSumanGastrointest.Disord.2024,6(2),368-379;doi.org/10.3390/gidisord(registering DOI)-28Mar2024AbstractTheentericnervoussystem(ENS),consistingofneuronsandglialcells,issituatedalongthegastrointestinal(GI)tract’swallandplaysacrucialroleincoordinatingdigestiveprocesses.RecentresearchsuggeststhattheoptimalfunctioningoftheGIsystemreliesonintricateconnections[...]Readmore.Theentericnervoussystem(ENS),consistingofneuronsandglialcells,issituatedalongthegastrointestinal(GI)tract’swallandplaysacrucialroleincoordinatingdigestiveprocesses.RecentresearchsuggeststhattheoptimalfunctioningoftheGIsystemreliesonintricateconnectionsbetweentheENS,theintestinalepithelium,theimmunesystem,theintestinalmicrobiome,andthecentralnervoussystem(CNS).Inflammatoryboweldisease(IBD)encompassesagroupofchronicinflammatorydisorders,suchasCrohn’sdisease(CD)andulcerativecolitis(UC),characterizedbyrecurringinflammationanddametotheGItract.ThisreviewexploresemergingresearchinthedynamicfieldofIBDandshedslightonthepotentialroleofENSalterationsinboththeetiologyandmanementofIBD.Specifically,wedelveintoIBD-inducedentericglialcell(EGC)activationanditsimplicationsforpersistententericgliosis,elucidatinghowthisactivationdisruptsGIfunctionthroughalterationsinthegut–brainaxis(GBA).Additionally,weexamineIBD-associatedENSalterations,focusingonEGCsenescenceandtheacquisitionofthesenescence-associatedsecretoryphenotype(SASP).WehighlightthepivotalroleofthesechangesinpersistentGIinflammationandtherecurrenceofIBD.Finally,wediscusspotentialtherapeuticinterventionsinvolvingsenotherapeuticents,providinginsightsintopotentialenuesformaningIBDbytargetingENS-relatedmechanisms.ThisapproachmightrepresentapotentialalternativetomaningIBDandadvancetreatmentofthismultifaceteddisease.Fullarticle22pes,3463KiB OpenAccessReviewRiseofWisdomPedogyResearchinHigherEducation(1980–2022):ASystematicLiteratureReviewbyMariaJakubikTrendsHigh.Educ.2024,3(2),199-220;doi.org/10.3390/higheredu(registering DOI)-28Mar2024AbstractThispaperexplores:Howhaswisdompedogyresearchemergedinhighereducationduring1980–2022?ThisstudyisthefirsttoexploretheemergenceofwisdompedogyresearchinhighereducationapplyingBipartitenetworkanalysisfordetectingclustersof24wisdompedogyarticlesof[...]Readmore.Thispaperexplores:Howhaswisdompedogyresearchemergedinhighereducationduring1980–2022?ThisstudyisthefirsttoexploretheemergenceofwisdompedogyresearchinhighereducationapplyingBipartitenetworkanalysisfordetectingclustersof24wisdompedogyarticlesof53authorsand161keywords.ResultsarevisualizedwithWoSanalytics,word-clouds,andwithBipartitenetwork.Wisdomresearchinhighereducationistwodecadeslatecomparedwithotherdisciplines.Inhighereducationn=524wisdom,n=33wisdompedogypublicationsweredetectedintheWebofScienceCoreCollectiondatabase.Thispaperanalyzedn=24wisdompedogyarticlespublishedduringthe1980–2022period.Therewereonlytwoarticlesfounddealingdirectlywithwisdompedogy.Therefore,thisstudyhasseveralfurtherresearchimplicationsforeducationalresearchers.Firstly,theyneedtoconductamorecomprehensivesearchforwisdompedogymodelsbyextendingthescopeofthisstudytootherdatabases,books,bookchapters,andtoconferencepapers.Secondly,theyneedtosynthesizeandtheorizetheirfindingsbybuildingawisdompedogymodel.Thirdly,researchersneedtodevelopdetailedguidelinesforeducationalpractitionersonhowtoapplywisdompedogyinpractice.Thisstudyisonlyatthebeginningofthisjourney.However,itwouldbeimportantforeducatingstudentswithwisdompedogyinhighereducationbecauseitwouldfacilitatestudents’thinking,judgements,andactionsbasedontheirmoralandethicalvaluesinahighlyinterconnectedandcomplexworld.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure911pes,3094KiB OpenAccessReviewOphthalmicManifestationsinPatientswithBloodMalignanciesbyCostanzaRossi,AlessandroBuizza,GiuseppeAlessio,MassimilianoBorselli,AndreaTaloni,AdrianoCarnevali,GiovannaCarnovaleScalzo,AndreaLucisano,VincenzoScorciaandGiuseppeGiannaccareHematol.Rep.2024,16(2),193-203;doi.org/10.3390/hematolrep(registering DOI)-28Mar2024AbstractOcularcomplicationscanoccurinupto90%ofpatientswithbloodmalignancies.Suchcomplicationsrangefromdirectinfiltrationtolocalhemostaticimbalanceandtreatment-relatedtoxicity.ThisnarrativereviewisbasedonasystematiccomputerizedsearchoftheliteratureconducteduntilJanuary2024[...]Readmore.Ocularcomplicationscanoccurinupto90%ofpatientswithbloodmalignancies.Suchcomplicationsrangefromdirectinfiltrationtolocalhemostaticimbalanceandtreatment-relatedtoxicity.ThisnarrativereviewisbasedonasystematiccomputerizedsearchoftheliteratureconducteduntilJanuary2024andexaminesthecommonocularcomplicationsassociatedwithbloodcancers.Ocularcomplicationsfromprimarydiseaseincludemasseffectsfromocularadnexallymphomasandintraocularlymphomas,withB-celllymphomasaccountingfor95%ofprimaryocularpresentations.Secondarydiseaseinvolvementfromsystemichematologicalmalignanciescanleadtoawiderangeofocularmanifestations,suchasleukemicretinopathy.Furthermore,toxicityfromantineoplastictherapiesandoculargraftversushostdisease(oGVHD)afterhematopoieticstemcelltransplantationpresentadditionalriskstoocularhealth.Inconclusion,ocularcomplicationsinbloodcancerpatientsareanintegralpartofpatientmanement,requiringregularophthalmicevaluationsandclosecollaborationbetweenoncologistsandophthalmologists.Advancesintherapyandanincreasedfocusonearlysymptomrecognitionareessentialforpreservingvisionandenhancingpatientqualityoflife.Fullarticle9658;9660;ShowFiguresFigure115pes,2185KiB OpenAccessArticleAugmentingtheAntitumorEfficacyofNaturalKillerCellsviaSynNotchReceptorEngineeringforTargetedIL-12SecretionbyAliAhmadnia,SaeedMohammadi,AhadYamchi,MohamadRezaKalani,TourajFarazmandfar,AyyoubKhosriandAliMemarianCurr.IssuesMol.Biol.2024,46(4),2931-2945;doi.org/10.3390/cimb(registering DOI)-28Mar2024AbstractNaturalkiller(NK)cellsarecrucialcomponentsofinnateimmunity,knownfortheirpotenttumorsurveillanceabilities.Chimericantigenreceptors(CARs)heshownpromiseincancertargeting,butoptimizingCARdesignsforNKcellfunctionalityremainschallenging.CAR-NKcellshegainedattentionfor[...]Readmore.Naturalkiller(NK)cellsarecrucialcomponentsofinnateimmunity,knownfortheirpotenttumorsurveillanceabilities.Chimericantigenreceptors(CARs)heshownpromiseincancertargeting,butoptimizingCARdesignsforNKcellfunctionalityremainschallenging.CAR-NKcellshegainedattentionfortheirpotentialtoreducesideeffectsandenablescalableproductionincancerimmunotherapy.ThisstudyaimedtoenhanceNKcellanti-tumoractivitybyincorporatingPD1-syntheticNotch(synNotch)receptors.AchimericreceptorwasdesignedusingUniProtdatabasesequences,and3Dstructuremodelsweregeneratedforoptimization.LentiviraltransductionwasusedtointroducePD1-SynreceptorsintoNKcells.TheexpressionofPD1-SynreceptorsonNKcellsurfaceswasassessed.EngineeredNKcellswereco-culturedwithPDL1+breastcancercellstoevaluatetheircytotoxicactivityandabilitytoproduceinterleukin-12(IL-12)andinterferon-gamma(IFNγ)uponinteractionwiththetargetcells.ThisstudysuccessfullyexpressedthePD1-SynreceptorsonNKcells.CAR-NKcellssecretedIL-12andexhibitedtarget-dependentIFNγproductionwhenengingPDL1+cells.Theircytotoxicactivitywassignificantlyenhancedinatarget-dependentmanner.ThisstudydemonstratesthepotentialofsynNotchreceptor-engineeredNKcellsinenhancinganti-tumorresponses,especiallyinbreastcancercaseswithhighPDL1expression.Fullarticle(ThisarticlebelongstotheSpecialIssueTargetingTumorMicroenvironmentforCancerTherapy,2ndEdition)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure611pes,664KiB OpenAccessArticleCanSecondaryAdhesiveCapsulitisComplicateCalcificTendinitisoftheRotatorCuff?AnUltrasoundImingAnalysisbyGiovanniTuè,OrianaMasuzzo,FrancescoTucci,MarcoCallo,AnnaParmeggiani,FabioVita,AlbertoPatti,DaniloDonati,AlessandroMarinelli,MarcoMiceliandPaoloSpinnatoClin.Pract.2024,14(2),579-589;doi.org/10.3390/clinpract(registering DOI)-28Mar2024AbstractBackground:Adhesivecapsulitis(AC)oftheglenohumeraljointisarecognizedcauseofpainassociatedwithbothactiveandpassiverestrictedrangesofmovement.ACcanbesubdividedintoprimaryandsecondaryforms.Trauma,surgery,immobilization,anddiabetesmellitusaretheleadingwell-recognized[...]Readmore.Background:Adhesivecapsulitis(AC)oftheglenohumeraljointisarecognizedcauseofpainassociatedwithbothactiveandpassiverestrictedrangesofmovement.ACcanbesubdividedintoprimaryandsecondaryforms.Trauma,surgery,immobilization,anddiabetesmellitusaretheleadingwell-recognizedcausesofsecondaryAC.Calcifictendinitis/tendinitis(CT)oftherotatorcuffisconsideredapossibletriggerforAC,asreportedinafewpreviousarticles.However,therearenooriginalinvestigationsthatassessthefrequencyandcharacteristicsofthisassociation.TheaimofourresearchwastoevaluatethepresenceofACinacohortofpatientswithaknownCTconditionoftherotatorcuffbyanultrasound(US)examination.Materialsandmethods:Weprospectivelyenrolledallthepatientsadmittedatoursingleinstitution(October2022–June2023)forthepreoperativeUSevaluationofaknownCTcondition.Inthesepatients,wesearchedforparametersrelatedtosecondaryAC.Anaxillarypouch(AP)thicknessequaltoorgreaterthan4mm(orgreaterthan60%ofthecontralateralAP)wasconsidereddinosticofAC.Moreover,rotatorinterval(RI)thicknessandthepresenceofeffusionwithinthelong-headbicepstendon(LHBT)sheathwasalsoassessedinallpatients.Results:Atotalof78patients(54F,24M—meane=50.0andrange=31–71y.o.)wereenrolledinthestudy.In26ofthosepatients(26/78—33.3%),USsignsofACweredetected.Notably,themeanAPthicknessinpatientswithACandCTwas3.96±1.37mm(Group1)and2.08±0.40mminpatientswithCTonly(Group2).RIthicknesswassignificantlygreaterinpatientswithsuperimposedAC:2.54±0.38mminGroup1and1.81±0.41mminGroup2(p<0.).Moreover,effusionwithintheLHBTwassignificantlymorefrequentlydetectedinpatientswithAC:84.61%inGroup1versus15.79%inGroup2—p<0..Conclusion:USsignsofACarefoundinone-thirdofpatientswithCToftherotatorcuff,demonstratingthatACrepresentsafrequentcomplicationthatshouldberoutinelyevaluatedduringUSinvestigationtoprovidemorepersonalizedtreatmentstrategies.Fullarticle(ThisarticlebelongstotheSpecialIssueShoulderDisorders:DinosisandTreatment)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,112KiB)9pes,1142KiB OpenAccessArticleEpidemiologyofHepatocellularCarcinomainTaiwanbyYu-WeiLaiandChing-HuChungClin.Pract.2024,14(2),570-578;doi.org/10.3390/clinpract(registering DOI)-28Mar2024AbstractBackground:Hepatocellularcarcinoma(HCC)isamajorcontributortotheworld’scancerburden.UnderstandingtheHCCincidencerateinTaiwanisthusaninterestingenueofresearch.Methods:FromanNHIdatabase,thosepatientswhohadbeennewlydinosedwithHCCandwho[...]Readmore.Background:Hepatocellularcarcinoma(HCC)isamajorcontributortotheworld’scancerburden.UnderstandingtheHCCincidencerateinTaiwanisthusaninterestingenueofresearch.Methods:FromanNHIdatabase,thosepatientswhohadbeennewlydinosedwithHCCandwhohadbeenlistedonaregistryinacatastrophicillnessdatasetduringtheyears2013–2021wereenrolledinthisstudy.Antineoplasticentuseandcomorbiditieswerealsostudied.Results:TheincidencerateofHCCdecreasedfrom57.77to44.95in100,000from2013to2021.TheereeofpatientswithHCCincreasedfrom65.54yearsoldwithaCCIscoreof4.98in2013to67.92yearsoldwithaCCIscoreof5.49in2021.AmongtheseHCCpatients,thepatientsunderantineoplasticenttreatmentdecreasedfrom53.47%to31.41%from2013to2021.ThepresenceofcomorbiditiesinHCCpatientswasabout55.77–83.01%withmildliverdiseaseand29.93–37.30%withdiabetes(withoutcomplications)intheperiod2013–2021.Conclusions:TheincidencerateofHCCslightlydecreasedinTaiwan.Duetoantineoplasticentusedecreasingovertime,theseresultsmayindicatethatmoreearly-steHCCpatientsdetectedinrecentyearsweremainlytreatedwithsurgeries.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure314pes,968KiB OpenAccessReviewDecodingPost-ViralFatigue:TheBasalGanglia’sComplexRoleinLong-COVIDbyThorstenRudroffNeurol.Int.2024,16(2),380-393;doi.org/10.3390/neurolint(registering DOI)-28Mar2024AbstractLong-COVIDafflictsmillionswithrelentlessfatigue,disruptingdailylife.Theobjectiveofthisnarrativereviewistosynthesizecurrentevidenceontheroleofthebasalgangliainlong-COVIDfatigue,discusspotentialmechanisms,andhighlightpromisingtherapeuticinterventions.Acomprehensiveliteraturesearchwas[...]Readmore.Long-COVIDafflictsmillionswithrelentlessfatigue,disruptingdailylife.Theobjectiveofthisnarrativereviewistosynthesizecurrentevidenceontheroleofthebasalgangliainlong-COVIDfatigue,discusspotentialmechanisms,andhighlightpromisingtherapeuticinterventions.AcomprehensiveliteraturesearchwasconductedusingPubMed,Scopus,andWebofSciencedatabases.MountingevidencefromPET,MRI,andfunctionalconnectivitydatarevealsbasalgangliadisturbancesinlong-COVIDexhaustion,includinginflammation,metabolicdisruption,volumechanges,andnetworkalterationsfocusedonstriataldopaminecircuitryregulatingmotivation.Theoriessuggestinflammation-inducedsignalingdisturbancescouldimpedeeffort/rewardvaluation,disruptcortical–subcorticalmotivationalpathways,ordiminishexcitatoryinputtoarousalcenters,attenuatingdriveinitiation.Recenttherapeuticpilotstargetingbasalgangliaabnormalitiesshowprovisionalefficacy.However,heterogeneousoutcomes,inconsistentmetrics,andperceivedversusobjectivefatiguediscrepanciestemperinsights.Despitethegrowingresearch,gapsremaininunderstandingtheprecisepathwayslinkingbasalgangliadysfunctiontofatigueandvalidatingtreatmentefficacy.Furtherresearchisneededtoadvanceunderstandingofthebasalganglia’scontributiontolong-COVIDneurologicalsequelaeandofferhopeforimprovingfunctionacrosstheexpandingaffectedpopulation.Fullarticle(ThisarticlebelongstotheSpecialIssueCOVID-19,NeuroinflammationandTherapeutics,2ndEdition)9658;9660;ShowFiguresFigure124pes,KiB OpenAccessArticleTowardsTransdisciplinaryHeriteAssessment:AnAnalysisoftheUseofLandscapeStudyMethodsasaHolisticToolboxforCulturalSiteCharacterisationintheSpanishContextbyCeliaLópez-BroArchitecture2024,4(2),197-220;doi.org/10.3390/architecture(registering DOI)-28Mar2024AbstractThisresearchworkarisesfromtheneedtodesignspecifictechniquesforthecharacterisationofculturalsites.Assumingtheincreasingcomplexityoftheprotectiontypologies,theexpansionofworkingscalesgivesthankstotechnologyandthepursuitofsocialsustainabilityobjectives.Thus,its[...]Readmore.Thisresearchworkarisesfromtheneedtodesignspecifictechniquesforthecharacterisationofculturalsites.Assumingtheincreasingcomplexityoftheprotectiontypologies,theexpansionofworkingscalesgivesthankstotechnologyandthepursuitofsocialsustainabilityobjectives.Thus,itsmainobjectiveistosearchforinnovativetoolsthatotherdisciplinescancontributetotheworkofarchitectsspecialisinginheritestudies.Tothisend,theresearchexploresthemainmethodologies,maps,guides,andregistersoflandscapeandhistoriclandscapecharacterisationdevelopedinEurope,particularlyinSpain,overthelast40years.Consideringthisintenseandprofoundevolutionoflandscapeanalysis,usefulstrategiesfortheassessmentofculturalsitesfromtheirconceptioninthe21stcenturyarise.Nevertheless,landscapecharacterisationmethodshebeenmainlydevelopedandappliedbygeographersandareabsentinmanyurbanandterritorialheritestudies.Inresponse,thisarticleproposesanewmethodologicalapproachfocusingoncontextualvaluestobeusedintheassessmentofarchitecturalheriteattheterritorialscale.Fullarticle(ThisarticlebelongstotheSpecialIssueConservationofArchitecturalHerite.NewUrbanPerspectives:Conceptual,Methodological,TechnicalandManementAdvances)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure1112pes,277KiB OpenAccessArticleDiracField,vanderWaalsGas,WeyssenhoffFluid,andNewtonParticlebyLucaFabbriFoundations2024,4(2),134-145;doi.org/10.3390/foundations(registering DOI)-28Mar2024AbstractThisarticleconsiderstheDiracfieldinpolarformulationandshowsthatwhentorsionistakenineffectiveapproximationthetheoryhasthethermodynamicpropertiesofavanderWaalsgas.Itisthenshownthatinthelimitofzerochiralangle[...]Readmore.ThisarticleconsiderstheDiracfieldinpolarformulationandshowsthatwhentorsionistakenineffectiveapproximationthetheoryhasthethermodynamicpropertiesofavanderWaalsgas.ItisthenshownthatinthelimitofzerochiralanglethevanderWaalsgasreducestoaWeyssenhofffluid,andinspinlessnessregimetheWeyssenhofffluidfurtherreducestoaNewtonparticle.Thisnestingofapproximationsallowsustointerpretthevariousspinorquantities.Wewillseethattorsionwillprovideaformofnegativepressure,whilethechiralanglewillberelatedtoatypeoftemperature.Fullarticle(ThisarticlebelongstotheSectionPhysicalSciences)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,347KiB)12pes,2818KiB OpenAccessArticleDeficiencyinDNADameRepairProteinsPromotesProstateCancerCellMigrationthroughOxidativeStressbyPhilippaLantwin,AdamKaczorowski,CathleenNientiedt,ConstantinSchwab,MartinaKirchner,ViktoriaSchütz,MdalenaGörtz,MarkusHohenfellner,AnetteDuensing,AlbrechtStenzingerandStefanDuensingOnco2024,4(2),56-67;doi.org/10.3390/onco(registering DOI)-28Mar2024AbstractIntroduction:DNAdamerepairgenedeficiencydefinesasubgroupofprostatecancerpatientswithearlymetastaticprogressionandunforablediseaseoutcome.WhetherdeficiencyinDNAdamerepairgenesdirectlypromotesmetastaticdisseminationisnotcompletelyunderstood.Methods:Themigratorybehiorofprostatecancer[...]Readmore.Introduction:DNAdamerepairgenedeficiencydefinesasubgroupofprostatecancerpatientswithearlymetastaticprogressionandunforablediseaseoutcome.WhetherdeficiencyinDNAdamerepairgenesdirectlypromotesmetastaticdisseminationisnotcompletelyunderstood.Methods:ThemigratorybehiorofprostatecancercellswasanalyzedaftersiRNA-mediatedknockdownofDNAdamerepairandcheckpointproteins,includingBRCA2,ATM,andothers,usingtranswellmigrationassays,scratchassaysandstainingforF-actintoascertaincellcircularity.CellsdeficientinBRCA2orATMweretestedforoxidativestressbymeasuringreactiveoxygenspecies(ROS).TheeffectsofROSinhibitiononcellmigrationwereanalyzedusingtheantioxidantN-acetylcysteine(NAC).ThecorrelationbetweenBRCA2deficiencyandoxidativestresswasascertainedviaimmunohistochemistryformethylglyoxal(MG)-modifiedproteinsin15geneticallydefinedprimaryprostatecancers.Results:ProstatecancercellsshowedasignificantlyincreasedmigratoryactivityaftertheknockdownofBRCA2orATM.TherewasasignificantincreaseinROSproductioninLNCaPcellsafterBRCA2knockdownandinPC-3cellsafterBRCA2orATMknockdown.Remarkably,theROSscengerNACabolishedtheenhancedmotilityofprostatecancercellsaftertheknockdownofBRCA2orATM.PrimaryprostatecancersharboringgeneticalterationsinBRCA2showedasignificantincreaseinMG-modifiedproteins,indicatingenhancedoxidativestressinvivo.Conclusions:OurresultsindicatethatDNAdamerepairgenedeficiencymaycontributetothemetastaticdisseminationofprostatecancerthroughenhancedtumorcellmigrationinvolvingoxidativestress.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7attachmentSupplementarymaterial:SupplementaryFile1(ZIP,731KiB)29pes,2707KiB OpenAccessArticleBCL2ProteinProgressivelyDeclinesduringRobustCLLClonalExpansion:PotentialImpactonVenetoclaxClinicalEfficacyandInsightsonMechanismbyHyunjooLee,ShabirulHaque,RashmiGupta,JonathanE.Kolitz,StevenL.Allen,KantiRai,NicholasChiorazziandPatriciaK.A.MonginiLymphatics2024,2(2),50-78;doi.org/10.3390/lymphatics(registering DOI)-28Mar2024AbstractCLLBcellsexpresselevatedpro-survivalBCL2,anditsselectiveinhibitor,venetoclax,significantlyreducesleukemiccellload,leadingtoclinicalremission.Nonetheless,relapsesoccur.ThisstudyevaluatesthehypothesisthatprogressivelydiminishedBCL2proteinincyclingCLLcellswithinpatientlymphnodeniches[...]Readmore.CLLBcellsexpresselevatedpro-survivalBCL2,anditsselectiveinhibitor,venetoclax,significantlyreducesleukemiccellload,leadingtoclinicalremission.Nonetheless,relapsesoccur.ThisstudyevaluatesthehypothesisthatprogressivelydiminishedBCL2proteinincyclingCLLcellswithinpatientlymphnodenichescontributestorelapse.UsingCFSE-labeled,purifiedCLLpopulationsknowntorespondwithvigorouscyclingind6culturesstimulatedwithTLR9-activatingODN(oligodeoxynucleotide)+IL15,weshowthatBCL2proteinprogressivelydeclinesduringconsecutivecelldivisions.Incontrast,MCL1andsurvivinaremaintained/slightlyelevatedduringcycling.DelayedpulsingofquiescentandactivatedCLLcultureswithselectiveinhibitorsofBCL2orsurvivinrevealedselectivetargetingofnoncyclingandcyclingpopulations,respectively,raisingimplicationsfortherapy.ToaddressthehypothesisthatBCL2-repressivemiRs(miR15a/miR16-1),encodedinChr13,aremechanisticallyinvolved,wecomparedBCL2proteinlevelswithinODN+IL15-stimulatedCLLcells,with/withoutdel(13q),yieldingresultssuggestingthesemiRscontributetoBCL2reduction.Insupport,withinODN-primedCLLcells,anIL15-drivenSTAT5/PI-3Kpathway(requiredforvigorouscycling)triggerselevatedp53TFproteinknowntodirectlyactivatethemiR15a/miR16-1locus.Furthermore,IL15signalingelicitsthTafadhali subiri… KivulierepressionofBCL2mRNAwithin24h.Additionalcomparisonsofdel(13q)+anddel(13q)−/−cohortsforelevatedp53TFexpressionduringcyclingsuggestthatadocumentedmiR15a/miR16-1-mediatednegativefeedbackloopforp53synthesisisactiveduringcycling.FindingsthatrobustCLLcyclingassociateswithprogressivelydecreasingBCL2proteinthatdirectlycorrelateswithdecreasingvenetoclaxsusceptibility,combinedwithpastfindingsthatthesecyclingcellshethegreatestpotentialforactivation-inducedcytosinedeaminase(AICDA)-drivenmutations,suggestthatvenetoclaxtreatmentshouldbeaccompaniedbymodalitiesthatselectivelytargetthecyclingcompartmentwithoutelicitingfurthermutations.Theemploymentofsurvivininhibitorsmightbesuchanapproach.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure718pes,627KiB OpenAccessArticleTheModeratingEffectofBodyAppreciationontheRelationshipbetweenSelf-EsteemandLifeSatisfactionbyRenéWodarzandAleksandraM.RogowskaEur.J.Investig.HealthPsychol.Educ.2024,14(4),870-887;doi.org/10.3390/ejihpe(registering DOI)-28Mar2024AbstractBackground:Althoughpositiveassociationsbetweenlifesatisfaction,self-esteem,andbodyimehepreviouslybeenestablished,differencesinthesevariablesbygenderandeheyieldedmixedresults.Moreover,littleisknownabouttheinterplaybetweenself-esteemandbodyappreciationonlifesatisfaction.This[...]Readmore.Background:Althoughpositiveassociationsbetweenlifesatisfaction,self-esteem,andbodyimehepreviouslybeenestablished,differencesinthesevariablesbygenderandeheyieldedmixedresults.Moreover,littleisknownabouttheinterplaybetweenself-esteemandbodyappreciationonlifesatisfaction.Thisstudyaimstoinvestigatethemoderatingeffectofbodyappreciationontherelationshipbetweenself-esteemandlifesatisfaction,consideringdisparitiesbetweenfemalesandmalesandalsobetweenemergingadults(beforetheeofthirty)andolderadults.Methods:Across-sectionalonlinesurveywasperformedinPolandwithasampleof449adultsedbetween18and75(M=30.41,SD=12.72),including68%ofwomen.ThesurveyincludedtheSatisfactionWithLifeScale(SWLS),RosenbergSelf-EsteemScale(RSES),andBodyAppreciationScale(BAS-2).Results:Menscoredhigherthanwomenintermsoflifesatisfactionandself-esteem,whileolderparticipants(e>30)scoredhigherthanyoungerindividuals(e≤30)intermsoflifesatisfaction,self-esteem,andbodyappreciation.Thestudyconfirmedpositiveandmoderatecorrelationsbetweenlifesatisfaction,self-esteem,andbodyappreciation.Theinteractiveeffectofself-esteemandbodyappreciationonlifesatisfactionwasalsofoundbycontrollingforeandgender.Conclusions:Someinterventionprogramsfocusedonincreasinglevelsofself-esteemandbodyappreciationshouldbeimplemented,especiallyamongwomenandemergingadults,toimprovetheirwell-being.Fullarticle(ThisarticlebelongstotheSpecialIssueBodyImePerceptionandBodyCompositioninAllPopulation)14pes,1018KiB OpenAccessArticleNocturnalSmartphoneUseAffectsSleepQualityandCognitiveandPhysicalPerformanceinTunisianSchool-eChildrenbyRihabAbid,AchrafAmmar,RamiMaaloul,MariemBoudaya,NizarSouissiandOmarHammoudaEur.J.Investig.HealthPsychol.Educ.2024,14(4),856-869;doi.org/10.3390/ejihpe(registering DOI)-28Mar2024AbstractNocturnalsmartphoneuseemitsbluelight,whichcanadverselyaffectsleep,leadingtoavarietyofnegativeeffects,particularlyinchildren.Therefore,thepresentstudyaimedtodeterminetheeffectofacute(AC)(onenight)andrepeated(RC)(fivenights)nocturnalsmartphoneexposure[...]Readmore.Nocturnalsmartphoneuseemitsbluelight,whichcanadverselyaffectsleep,leadingtoavarietyofnegativeeffects,particularlyinchildren.Therefore,thepresentstudyaimedtodeterminetheeffectofacute(AC)(onenight)andrepeated(RC)(fivenights)nocturnalsmartphoneexposureonsleep,cortisol,andnext-dayperformanceinTunisianchildren.Thirteenparticipants(sevengirlsandsixboys,e9±0.6,height1.32±0.06,weight34.47±4.41)attendedsixexperimentalnights.Theexperimentstartedwithabaselinenight(BL)withnosmartphoneexposure,followedbyrepeatedsessionsofnocturnalsmartphoneexposurelasting90minutes(08:00pm–09:30pm).Actigraphy;salivarycortisol;theStrooptest(selectiveattention);choicereactiontime(CRT);N-back(workingmemory);counter-movementjump(CMJ),composedofflighttime(timespentintheCMJflightphase)andjumpheight;anda30msprintwereassessedthemorningaftereachcondition.BothACandRCshortenedtotalsleeptime(TST)(p<0.01),withagreaterdecreasewithRC(−46.7min,8710;%=−9.46)thanAC(−28.8min,8710;%=−5.8)comparedtoBL.ACandRCsignificantlyincreasedwakingaftersleeponset(3.5min,8710;%=15.05,to9.9min,8710;%=43.11%)andnumberoferrorsmadeontheStrooptest(1.8error,8710;%=74.23,to3.07error,8710;%=97.56%).Childrenmade0.15and0.8moreerrors(8710;%=6.2to57.61%)andspent46.9sand71.6smoretimeonCRTtasks(8710;%=7.22to11.11%)withACandRC,respectively,comparedtoBL.Thehigh-interferenceindexoftheStrooptask,CMJperformance,and30msprintspeedwereonlyaltered(p<0.01)followingRC(0.36,Δ%=41.52%;−34s,Δ%=−9.29%,forflighttimeand−1.23m,−8.72%,forjumpheight;0.49s,Δ%=6.48,respectively)whencomparedtoBL.Inconclusion,one-orfive-nightexposuretosmartphonesdisturbedthechildren’ssleepqualityandtheirperformance,withmorepronouncedeffectsfollowingRC.Fullarticle9658;9660;ShowFiguresFigure111pes,1108KiB OpenAccessArticleEmergencyFirstResponders’MisconceptionsaboutSuicide:ADescriptiveStudybyElenaVictoriaAyalaRomera,RosaMaríaSánchezSantos,GiulioFenzi,JuanAntonioGarcíaMéndezandJoseLuisDíazeaNurs.Rep.2024,14(2),777-787;doi.org/10.3390/nursrep(registering DOI)-28Mar2024AbstractBackground:In2022,suicidewasthesecondleadingcauseofexternaldeathinSpain(thefirstamongyoungpeopleed15–29years).Thisstudyaimstoanalyzethepresenceofmythsamongemergencyfirstrespondersandidentifythemostprevalentfalsebeliefsamong[...]Readmore.Background:In2022,suicidewasthesecondleadingcauseofexternaldeathinSpain(thefirstamongyoungpeopleed15–29years).Thisstudyaimstoanalyzethepresenceofmythsamongemergencyfirstrespondersandidentifythemostprevalentfalsebeliefsamongthem.Methods:Theresearchisaobservationalanddescriptivestudycarriedoutusingaquestionnairecomposedofatotalof25myths,withtheresponseoptionsbeingtrueorfalse.Atotalof543professionalstookpartinthestudy.Allofthemcouldintervenebefore,during,andafterasuicideattempt.Results:Themainfindingofthestudyisthatmorethan50%oftheparticipantsacceptastruethestatement"Therearemoreseriousandlessseriousproblems",underliningtheideathatcaringforpatientscouldberelatedtotheimportancethehealthprofessionalgivestothepatients’problem.Mythssuchas“Thesuicidalpersonwantstodie”and“Thesuicidalpersonisdeterminedtodie”arealsoevident.Conclusion:Thesubjectivethoughtthefirstresponderhasaboutsuicidecouldaffecttheiracts,andthereisaneedtotrainfirstrespondersinsuicidalbehiortobeabletocreateanadequateapproach.Fullarticle(ThisarticlebelongstotheSpecialIssueNursingCareandClinicalManementinthePost-PandemicEra)9658;9660;ShowFiguresFigure1Figure2---Figure318pes,1675KiB OpenAccessArticleAdaptiveControlofQuadrotorsinUncertainEnvironmentsbyDanielLeitão,RitaCunhaandJoãoM.LemosEng2024,5(2),544-561;doi.org/10.3390/eng(registering DOI)-28Mar2024AbstractTheproblemaddressedinthisarticleconsistsofthemotioncontrolofaquadrotoraffectedbymodeldisturbancesanduncertainties.Inordertotacklemodeluncertainty,adaptivecontrolbasedonreinforcementlearningisused.Thedistinctivefeatureofthisarticle,incomparisonwith[...]Readmore.Theproblemaddressedinthisarticleconsistsofthemotioncontrolofaquadrotoraffectedbymodeldisturbancesanduncertainties.Inordertotacklemodeluncertainty,adaptivecontrolbasedonreinforcementlearningisused.Thedistinctivefeatureofthisarticle,incomparisonwithotherworksonquadrotorcontrolusingreinforcementlearning,istheexplorationoftheunderlyingoptimalcontrolprobleminwhichaquadraticcostandalineardynamicsallowforanalgorithmthatrunsinrealtime.Insteadofidentifyingaplantmodel,adaptationisobtainedbyapproximatingtheperformanceindexgivenbytheQ-functionusingdirectionalforgettingrecursiveleastsquaresthatrelyonalinearregressorbuiltfromquadraticfunctionsofinput/outputdata.Theadaptivealgorithmproposedistestedinsimulationinacascadecontrolstructurethatdrivesaquadrotor.Simulationsshowtheimprovementinperformancethatresultswhentheproposedalgorithmisturnedon.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure1225pes,KiB OpenAccessArticleAuthenticRomanianGastronomy—ALandmarkofBucharest’sCityCenterbyAna-IrinaLequeux-Dincă,MihaelaPredaandIulianaVijulieTour.Hosp.2024,5(2),251-275;doi.org/10.3390/tourhosp(registering DOI)-28Mar2024AbstractGastronomyrepresentsoneofthemaindefiningnationalculturalelementsandisessentialforshapingterritorialidentitiesandfortourismdevelopment,attractingbothdomesticandinternationaltourists.ThelandscapeinthecenterofBucharesthasgraduallychangedundertheinfluenceofentrepreneurialinitiatives[...]Readmore.Gastronomyrepresentsoneofthemaindefiningnationalculturalelementsandisessentialforshapingterritorialidentitiesandfortourismdevelopment,attractingbothdomesticandinternationaltourists.ThelandscapeinthecenterofBucharesthasgraduallychangedundertheinfluenceofentrepreneurialinitiativeswithinthehospitalityindustry,showingatpresentarathercosmopolitanurbanenvironment.Despitethesignificantnumberofinternationalcateringunits,betteradaptedtoglobaltastes,Romanian-themedrestaurantsrepresentalandmarkofthecapitalcity.Inthiscontext,ourstudyfocusesontheRomanianauthenticlocalgastronomyofferedbythethemedtraditionalrestaurantsinthecenterofBucharestasastimulatingfactorfordifferenttypesofconsumers.Aimingtoanswerseveralresearchquestions,thisresearchhasacomplexmulti-foldmethodologicalapproach,appealingtotriangulationwhichgathered,asmainanalyticmethods,mapping,semanticanalyses,andtextvisualisation,andtheinterviewmethod(originallyandappropriatelyappliedforthiscasestudytoexperiencedemployees).ThemainresultsshowacomplexgastronomiclandscapethatgathersvarioustypesofrestaurantsbutoutlinesthosewithaRomanianethnicthemeinthecenterofBucharest.ThestudyofRomanianrestaurants’menusrevealselementsofauthenticity(e.g.,traditionaldishesandtheirregionaldenominations,localruralingredients,oldrecipes,andcuisinetechniques)asfactorsofattractivenessforconsumersandascompetitiveadvantesintheirmarket.Moreover,interviewswithstaffrepresentativesoutlinerestaurants’atmosphere,originality,andprice–qualityratiooftheirfoodasthemainattractiveelementsforbothautochtonouscustomersandtouristsandwhichofferanadvanteinthemarket.Thepresentstudymayinterestmultiplestakeholders,focusingonthedevelopmentandevolutionofthehospitalityindustryinRomania.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure1415pes,2906KiB OpenAccessArticleAlleviatingSaltStressinTomatoesthroughSeedPrimingwithPolyethyleneGlycolandSodiumChlorideCombinationbyNasratullahHabibi,NaokiTerada,AtsushiSanadaandKaiheiKoshioStresses2024,4(2),210-224;doi.org/10.3390/stresses(registering DOI)-28Mar2024AbstractTomatocultivationgrappleswithsaltstress,disruptinggrowthparametersandphysiologicalprocesses.Highsalinitylevelsinduceosmoticstress,impactingcellularintegrityandhinderingmetabolicactivities.Saltaccumulationattherootzonealterskeyphysiologicalattributes,compromisingoverallharvestableoutput.Seedprimingemergesas[...]Readmore.Tomatocultivationgrappleswithsaltstress,disruptinggrowthparametersandphysiologicalprocesses.Highsalinitylevelsinduceosmoticstress,impactingcellularintegrityandhinderingmetabolicactivities.Saltaccumulationattherootzonealterskeyphysiologicalattributes,compromisingoverallharvestableoutput.Seedprimingemergesasapotentialsolutiontoenhanceplantresilience.Aresearchgapexistsinunderstandingthecombinedinfluenceofpolyethyleneglycolandsodiumchlorideasseedprimingentsundersaltstressconditions.ThestudyoccurredintheGreenhouseofLaboratoryHorticulturalScienceatTokyoUniversityofriculture.MicroTomseedsunderwentafactorialrandomizeddesign,involvingfivesalinityandfourprimingtreatments.Replicatedtentimes,totaling200plants,seedprimingusedpolyethyleneglycol,inducingsalinitystresswithsodiumchloride.Meticulousmeasurementsofgrowthparameters,photosynthetictraits,yieldattributes,andelectrolyteleakewereconducted.Statisticalanalysesdiscernedtreatmenteffectsata5%significancelevel.Seedpriming,especiallywith‘PEGplusNaCl’,effectivelymitigatedsaltstresseffectsontomatoplants.Underseveresaltstress,primedplantsexhibitedincreasedplantheight,trusses,lees,andleafarea.Photosyntheticefficiencyandyieldattributesdemonstratedsignificantimprovementswithseedpriming.Electrolyteleake,indicativeofleafdame,wasnotablyreducedbyseedprimingtreatments,with‘PEGplusNaCl’exhibitingthehighestefficacy.Theseresultsoffervaluableguidanceforoptimizingriculturalpracticesinsalineenvironments,contributingtosustainablestrategiesforfoodsecurityamidstescalatingenvironmentalchallenges.Fullarticle(ThisarticlebelongstotheSectionPlantandPhotoautotrophicStresses)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenicaActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEngEngineeringProceedingsEntropyEnvironmentalSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFireFishesFluidsFoodsForecastingForensicSciencesForestsFossilStudiesFoundationsFractalandFractional(FractalFract)FuelsFutureFutureInternetFuturePharmacologyFutureTransportationGalaxiesGamesGasesGastroenterologyInsightsGastrointestinalDisordersG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